Efficient Task Scheduling and Fair Load Distribution Among Federated Clouds

The federated cloud is the future generation of cloud computing, allowing sharing of computing and storage resources, and servicing of user tasks among cloud providers through a centralized control mechanism. However, a great challenge lies in the efficient management of such federated clouds and fair distribution of the load among heterogeneous cloud providers. In our proposed approach, called QPFS_MASG, at the federated cloud level, the incoming tasks queue are partitioned in order to achieve a fair distribution of the load among all cloud providers of the federated cloud. Then, at the cloud level, task scheduling using the Modified Activity Selection by Greedy (MASG) technique assigns the tasks to different virtual machines (VMs), considering the task deadline as the key factor in achieving good quality of service (QoS). The proposed approach takes care of servicing tasks within their deadline, reducing service level agreement (SLA) violations, improving the response time of user tasks as well as achieving fair distribution of the load among all participating cloud providers. The QPFS_MASG was implemented using CloudSim and the evaluation result revealed a guaranteed degree of fairness in service distribution among the cloud providers with reduced response time and SLA violations compared to existing approaches. Also, the evaluation results showed that the proposed approach serviced the user tasks with minimum number of VMs

Recent Advances Of Biotechnology In Medicine And Pharmacology

The term Biotechnology in the field of the medicines and pharmacology are very useful for the development and growth in production of medicines and drugs. Its applications in the fields of industries related to the medicine and agriculture are very wide. The development, enhancement, and the usage of modern and innovative techniques, procedures including the production of the personalized medicines and technologies related to CRISPR. The main aim of the present study is to show the role and usage of the innovative and modern approaches that are used by the biotechnology in the fields of the medicine and pharmacology. The collection, gathering, assembling of information and knowledge that are done by using the secondary sources, explaining the importance and benefits of the biotechnology including interpretivism philosophy. Explanation of various analysis that includes the development of various antibiotics, medicines and drugs that are made by the modern biotechnological processes

COLD STRESS INDUCED MODULATIONS ON ANTIOXIDANT STATUS OF STZ INDUCED DIABETIC FEMALE RAT REPRODUCTIVE SYSTEM: A PROTECTIVE ROLE OF TRIBULUS TERRESTRIS FRUIT EXTRACT

Diabetes mellitus induced oxidative stress could lead to the impairment of female reproductive antioxidant defense mechanism and low temperature exposure leads to oxidative stress as well. There is a positive relationship between hypothalamic noradrenergic neuronal activity and blood glucose concentrations under stressful conditions. Treatment of female reproductive disorders using herbal remedies is gaining popularity in human medicine. In light of this, the study was designed to investigate the effectiveness of TTF ethanol extract in STZ-induced diabetic female rat reproductive system exposed to cold stress and to evaluate their therapeutic potential for the treatment of cold stress induced modulations on antioxidant status of DM.  Diabetic rats exposed to cold stress by housing in an acute cold stress apparatus at 4±2 °C for 3hrs per day for 7 days later they were supplemented with TTF extract at a dose of 200mg/kgbw. To check the efficacy of TTF on oxidative stress indices in uterus, ovary and oviduct, the animals were sacrificed on the 19th day of TTF extract exposure and subjected to in vivo biochemical and hormonal assays.  The findings of this study confirm the deleterious effect of diabetes and cold stress on the reproductive organs weight, antioxidant defense system and hormones of female reproductive organs viz uterus, ovary and oviduct.  Supplementation of TTF (200mg/kgbw) extract to diabetic rats exposed to cold stress, the serum glucose levels decreased significantly (P<0.05) and significantly increased the weights of reproductive organs and serum oestrogen, FSH and LH levels when compared with the intoxicated control groups.  Diabetes toxicity and cold stress in the female reproductive organs may result in disruption of oxidants and antioxidants balances, which provides a strong coupling of altered equilibrium processes and loss of energy capacity to meet an oxidation challenge. Moreover, exposure to diabetes and cold stress can increase the effects of oxidative stress. Exogenous supplementation of TTF extract has been found to counter free radical generated oxidative stress and to facilitate reduction of the toxic effects induced by diabetes and cold stress, there by strengthening the cellular antioxidant defense and improved reproductive functioning ability